Germline APOE ε2 homozygosity and reduced risk of breast cancer: a population-based cohort study
Hwamin Woo, Suhyun Han, Jihye Heo, Juhee Cho, Do-Geun Kim, Chi-Hun Kim, Danbee Kang · 2026
Read Germline APOE ε2 homozygosity and reduced risk of breast cancer: a population-based cohort study by Hwamin Woo, Suhyun Han, Jihye Heo, Juhee Cho, Do-Geun Kim, Chi-Hun Kim, Danbee Kang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13371704.txt.
Description
Hwamin Woo and colleagues test whether carrying two copies of the APOE epsilon2 variant lowers breast cancer risk in a 2026 cohort study. APOE epsilon2 is linked to lower LDL cholesterol. Data from 234,857 women in the UK Biobank who were free of cancer and dementia were analysed, with new breast cancers tracked through national registries over a median of 12.3 years.
During follow-up, 7,961 first primary breast cancers occurred. Women with two epsilon2 copies had about 36 percent lower risk than non-carriers, and the protective link was stronger among those with a smoking history. The authors argue that genetically set lipid and inflammation control may shape breast cancer susceptibility, especially under inflammatory stress. The finding is observational and needs replication.
Catalog record
| CREATOR | Hwamin Woo, Suhyun Han, Jihye Heo, Juhee Cho, Do-Geun Kim, Chi-Hun Kim, Danbee Kang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |