Checkpoint kinase 2 coordinates autophagy activation and Aurora kinase A degradation to regulate primary cilia for cell invasion
Chia-Yih Wang, Yu-Ying Chao, Ting-Yu Chen, Ruei-Ci Lin, Hui-Man Tsai, Hsiao-Han Huang, Zi-Rong Chen, Fu-I Lu, Yu-Chi Su, Bon-chu Chung · 2026
Read Checkpoint kinase 2 coordinates autophagy activation and Aurora kinase A degradation to regulate primary cilia for cell invasion by Chia-Yih Wang, Yu-Ying Chao, Ting-Yu Chen, Ruei-Ci Lin, Hui-Man Tsai, Hsiao-Han Huang, Zi-Rong Chen, Fu-I Lu, Yu-Chi Su, Bon-chu Chung (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13371562.txt.
Description
Chia-Yih Wang and colleagues explain how the tumour suppressor CHEK2 maintains primary cilia, the cell antenna, in a 2026 study. CHEK2 is known for guarding genome integrity in the nucleus, and it also sits at the mother centriole, yet its role there was unclear. Using cultured cells and zebrafish, the team blocked or altered CHEK2 and ran rescue tests.
When nutrients were scarce, CHEK2 switched on to preserve cilia by breaking down Aurora kinase A, which would otherwise degrade the cilium shaft, and by activating AMPK to promote autophagy. Both routes were needed for placental cell ciliation, movement, and invasion. In pancreatic cancer cells, glutamine shortage triggered the same CHEK2 programme. The work links a DNA guardian to cell sensing and invasion.
Catalog record
| CREATOR | Chia-Yih Wang, Yu-Ying Chao, Ting-Yu Chen, Ruei-Ci Lin, Hui-Man Tsai, Hsiao-Han Huang, Zi-Rong Chen, Fu-I Lu, Yu-Chi Su, Bon-chu Chung |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |