Retrospective Identification and Quantitative Image Analysis of the ICAP Nuclear Pattern AC‐30 in Antinuclear Antibody Testing
Changmeng Wu, Wenhan Du, Weidong Chen, Juan He, Linlin Xu, Yu Li · 2026
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Description
Changmeng Wu and colleagues give the newly coded AC-30 antinuclear antibody pattern a quantitative profile in a 2026 study. The pattern shows fine speckled staining in cell nuclei and staining of metaphase chromatin, but its clinical meaning was unclear. Archived HEp-2 test images were scored by three blinded experts, with AC-1 and AC-2 patterns as comparators.
The AC-30 set held 183 images. Over half had no autoimmune diagnosis or an unknown one, about one quarter had another autoimmune disease, and about one sixth had an ANA-linked rheumatic disease. Rheumatoid arthritis accounted for about one sixth of AC-30 cases. Image measures showed lower per-nucleus intensity than comparators. The work gives labs an objective anchor for a pattern that was previously judged by eye alone.
Catalog record
| CREATOR | Changmeng Wu, Wenhan Du, Weidong Chen, Juan He, Linlin Xu, Yu Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |