Use of argatroban as anticoagulation for cardiopulmonary bypass during heart transplantation: A case report
Marika Faggioli, Daniela Bacich, Chiara Tessari, Fabio Zanella, Demetrio Pittarello, Annalisa Angelini, Augusto D’Onofrio, Vincenzo Tarzia, Gerosa Gino · 2026
Read Use of argatroban as anticoagulation for cardiopulmonary bypass during heart transplantation: A case report by Marika Faggioli, Daniela Bacich, Chiara Tessari, Fabio Zanella, Demetrio Pittarello, Annalisa Angelini, Augusto D’Onofrio, Vincenzo Tarzia, Gerosa Gino (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13371257.txt.
Description
Marika Faggioli and co-authors report a fatal complication when a substitute blood thinner was used during a heart transplant. The patient had heparin-induced thrombocytopenia, a reaction that bans the standard thinner, heparin, from the heart-lung machine. He also carried a mechanical heart pump from earlier care.
The team chose argatroban, one of two accepted substitutes, and dosed it by the book. During surgery, though, attempts to reverse the drug failed. Uncontrolled bleeding followed, and the patient died from the hemorrhage. The authors do not reject the drug outright. They call it a workable option for selected patients, but urge far more study and special caution for patients with heart pumps.
Catalog record
| CREATOR | Marika Faggioli, Daniela Bacich, Chiara Tessari, Fabio Zanella, Demetrio Pittarello, Annalisa Angelini, Augusto D’Onofrio, Vincenzo Tarzia, Gerosa Gino |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 11 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |