Gene regulatory network analysis identifies dysregulation of hypoxia pathways as contributing to glioblastoma treatment resistance in females
Tomisin Adebari, Viola Fanfani, Marouen Ben Guebila, Derrick DeConti, Katherine Hoff Shutta, Camila M Lopes-Ramos, Lauren Hsu, Dawn L DeMeo, John Quackenbush, Tara Eicher · 2026
Read Gene regulatory network analysis identifies dysregulation of hypoxia pathways as contributing to glioblastoma treatment resistance in females by Tomisin Adebari, Viola Fanfani, Marouen Ben Guebila, Derrick DeConti, Katherine Hoff Shutta, Camila M Lopes-Ramos, Lauren Hsu, Dawn L DeMeo, John Quackenbush, Tara Eicher (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13371200.txt.
Description
Adebari and co-authors study sex linked paths in glioblastoma, a fast growing brain tumor, in a 2026 paper. The tumor resists treatment and survival is short, yet rates and outcomes differ between males and females. The team asked whether gene control networks differ by sex in ways that help the tumor resist care.
They built gene networks from RNA data for low grade glioma and glioblastoma, split by sex, and checked the results in a second data set. In females, low oxygen paths and linked programs for sugar use, defense, and tissue matrix were more tightly co-regulated. The authors link that pattern to treatment resistance in females and call for sex aware study.
Catalog record
| CREATOR | Tomisin Adebari, Viola Fanfani, Marouen Ben Guebila, Derrick DeConti, Katherine Hoff Shutta, Camila M Lopes-Ramos, Lauren Hsu, Dawn L DeMeo, John Quackenbush, Tara Eicher |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |