APOE4 negates the effects of ovarian hormones on cerebrovascular endothelial and mitochondrial function

Mackenzie N Kehmeier, Alexandra Famiano, Abigail E Cullen, Thomas Leonhardt, Skylyn J Ferguson, Madeleine Snyder, Carrie E McCurdy, Daniel J Tyrrell, Nabil J Alkayed, Ashley E Walker · 2026

Read APOE4 negates the effects of ovarian hormones on cerebrovascular endothelial and mitochondrial function by Mackenzie N Kehmeier, Alexandra Famiano, Abigail E Cullen, Thomas Leonhardt, Skylyn J Ferguson, Madeleine Snyder, Carrie E McCurdy, Daniel J Tyrrell, Nabil J Alkayed, Ashley E Walker (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13370724.txt.

Description

Mackenzie Kehmeier and co-workers test in 2026 if a risk gene form wipes out the good that female hormone does for brain vessels in mice. The gene form and low hormone both lift brain ill risk in women. Young she mice of two gene forms get womb cuts, hormone adds, or no touch, all on a fat diet.

In the low risk form, womb cut hurts vessel stretch and hormone heals it. In the risk form, neither step moves vessel work. Hormone lifts cell breath in low risk brains lone. Gene form may set who gains from hormone care.

Catalog record

CREATORMackenzie N Kehmeier, Alexandra Famiano, Abigail E Cullen, Thomas Leonhardt, Skylyn J Ferguson, Madeleine Snyder, Carrie E McCurdy, Daniel J Tyrrell, Nabil J Alkayed, Ashley E Walker
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE56750
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13370724

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