Caloric restriction decelerates premature aging and cognitive decline in mice with deficient DNA repair
Chris Z Wei, Yejie Shi, Wenting Zhang, Sulaiman H Hassan, Ruyu Shi, Hongjian Pu, Hongfeng Mu, R Anne Stetler, Rehana K Leak, Jun Chen · 2026
Read Caloric restriction decelerates premature aging and cognitive decline in mice with deficient DNA repair by Chris Z Wei, Yejie Shi, Wenting Zhang, Sulaiman H Hassan, Ruyu Shi, Hongjian Pu, Hongfeng Mu, R Anne Stetler, Rehana K Leak, Jun Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13369994.txt.
Description
Chris Wei and co-authors test diet limits in fast aging mice in a 2026 study. DNA damage piles up with age and drives cell aging, and a repair enzyme called Apex1 guards the brain genome. Mice bred to lack Apex1 in front brain neurons aged early, with weak learning and memory from young ages.
By mid life those mice showed lost synaptic proteins, warped neuron shapes, and dulled synaptic strength. A diet cut by about a third, run from youth to mid life, eased the early aging signs and lifted thinking scores. The work marks Apex1 as a core guard and diet as a brake worth probing.
Catalog record
| CREATOR | Chris Z Wei, Yejie Shi, Wenting Zhang, Sulaiman H Hassan, Ruyu Shi, Hongjian Pu, Hongfeng Mu, R Anne Stetler, Rehana K Leak, Jun Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |