Evolutionary remodeling of ubiquinone biosynthesis in Toxoplasma gondii reveals an essential bi-functional monooxygenase
Baihetiya Baierna, Taufiq Rahman, Scott Latimer, Gilles J Basset, Silvia N J Moreno · 2026
Read Evolutionary remodeling of ubiquinone biosynthesis in Toxoplasma gondii reveals an essential bi-functional monooxygenase by Baihetiya Baierna, Taufiq Rahman, Scott Latimer, Gilles J Basset, Silvia N J Moreno (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13369981.txt.
Description
Baihetiya Baierna and co-authors map how a common parasite builds a molecule it cannot live without. The parasite, Toxoplasma gondii, infects a huge share of humanity. The molecule, ubiquinone, powers its energy machinery. The team traced the parasite's stripped-down version of the pathway and tested which parts are essential.
Two known enzymes proved vital for growth and for healthy energy organelles, and they sit together in one protein complex. The team also found a new enzyme, TgCoqFMO, that does two chemical steps alone, where other creatures use two separate enzymes. Blocking this enzyme slowed the parasite's fast form and weakened its dormant form. The authors name it a promising drug target, since the human pathway differs.
Catalog record
| CREATOR | Baihetiya Baierna, Taufiq Rahman, Scott Latimer, Gilles J Basset, Silvia N J Moreno |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |