Phase separation of a heterochiral peptide-drug conjugate amplified by ionic interactions
Yangkai Zhou, Jinmin Ye, Xingru Liu, Shijian Liang, Huipeng Ma, Xinghua Shi, Hui Wang, Jiayang Li, Chunying Chen · 2026
Read Phase separation of a heterochiral peptide-drug conjugate amplified by ionic interactions by Yangkai Zhou, Jinmin Ye, Xingru Liu, Shijian Liang, Huipeng Ma, Xinghua Shi, Hui Wang, Jiayang Li, Chunying Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13369861.txt.
Description
Yangkai Zhou and eight co-authors tune droplet formation in a peptide-drug molecule by chirality in a 2026 paper. Cells organize chemistry in liquid droplets without membranes, and engineers want synthetic versions. Precise chemical control of such droplets has been hard to achieve.
Their molecule alternates left- and right-handed building blocks along a short peptide carrying a drug. That mixed handedness favors liquid droplets over solid fibers. Common salts stabilize the droplets by interacting with the peptide. Single-handed versions instead formed sheet-rich gels. The phase behavior changed how cells took up the drug and how the liver processed it. One residue's handedness alone could flip the outcome. The work offers a design knob for droplet-based drug delivery.
Catalog record
| CREATOR | Yangkai Zhou, Jinmin Ye, Xingru Liu, Shijian Liang, Huipeng Ma, Xinghua Shi, Hui Wang, Jiayang Li, Chunying Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |