KIAA1199 aggravates sepsis-induced lung injury by promoting complement activation
Yang Qin, Jiani Zhang, Yanwen Zhang, Sunwang Ling, Weikang Ren, Li Liu, Shengwei Jin, Jianguang Wang, Xinyu Yang · 2026
Read KIAA1199 aggravates sepsis-induced lung injury by promoting complement activation by Yang Qin, Jiani Zhang, Yanwen Zhang, Sunwang Ling, Weikang Ren, Li Liu, Shengwei Jin, Jianguang Wang, Xinyu Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13369189.txt.
Description
Yang Qin and co-authors show that a protein best known from cancer worsens sepsis lung injury by switching on complement in a 2026 study. Sepsis, the body's runaway response to infection, often floods and scars the lungs, and that injury kills many patients. KIAA1199, also called CEMIP, had been tied to bacterial infection but not to this lung damage.
The team found the protein raised in patients' blood and traced its harm to complement activation, the immune cascade that tags invaders but can burn host tissue. Blocking that axis could protect lungs without weakening infection fighting elsewhere. Their findings nominate both a biomarker for risk and a drug target in a condition that still lacks specific therapy.
Catalog record
| CREATOR | Yang Qin, Jiani Zhang, Yanwen Zhang, Sunwang Ling, Weikang Ren, Li Liu, Shengwei Jin, Jianguang Wang, Xinyu Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |