Sequential versus upfront oxaliplatin-based therapy in metastatic colorectal cancer: long-term outcomes of a randomized phase 3 trial
Makoto Okawaki, Mototsugu Shimokawa, Ryo Inada, Hitoshi Ojima, Hiroaki Tanioka, Shingo Noura, Yoshinori Munemoto, Keiichiro Ishibashi, Yoshiaki Shindo, Madoka Hamada, Masasumi Okajima, Yoshiyuki Yamaguchi, Takeshi Yamada, Yasuhiro Shimada, Takeshi Nagasaka · 2026
Read Sequential versus upfront oxaliplatin-based therapy in metastatic colorectal cancer: long-term outcomes of a randomized phase 3 trial by Makoto Okawaki, Mototsugu Shimokawa, Ryo Inada, Hitoshi Ojima, Hiroaki Tanioka, Shingo Noura, Yoshinori Munemoto, Keiichiro Ishibashi, Yoshiaki Shindo, Madoka Hamada, Masasumi Okajima, Yoshiyuki Yamaguchi, Takeshi Yamada, Yasuhiro Shimada, Takeshi Nagasaka (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13369168.txt.
Description
Makoto Okawaki and co-authors report long term results of a phase 3 trial on when to add a strong drug in metastatic bowel cancer. Their 2026 report comes from a Japanese trial with 311 patients randomized. Three hundred entered the full analysis. One group started with a milder pairing and added oxaliplatin only when the cancer grew. The other got all three drugs from the start.
Survival was nearly identical between the strategies. Median survival was 27.2 months for the staged approach and 27.4 months upfront. The hazard ratio sat at 1.00, squarely neutral. Extra analyses by time window and milestone agreed. Age did not change the relative effect, a point of interest since older patients are scarce in trials. Quality of life was tracked with patient questionnaires as a preset outcome.
Catalog record
| CREATOR | Makoto Okawaki, Mototsugu Shimokawa, Ryo Inada, Hitoshi Ojima, Hiroaki Tanioka, Shingo Noura, Yoshinori Munemoto, Keiichiro Ishibashi, Yoshiaki Shindo, Madoka Hamada, Masasumi Okajima, Yoshiyuki Yamaguchi, Takeshi Yamada, Yasuhiro Shimada, Takeshi Nagasaka |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |