Keratin 1 and keratin 18 as immunohistochemical markers for distinguishing pulmonary metastases of oral squamous cell carcinoma from primary lung squamous cell carcinoma
Yoshiko Watanabe, Hisami Kato, Rei Ishikawa, Kimio Yoshimura, Hidetaka Yamada, Ryosuke Miyazaki, Sayuri Takeuchi, S M Jahurul Haque, Katsuhiro Yoshimura, Yasuhiro Sakai, Miki Sugita, Yusuke Inoue, Yusuke Takanashi, Keigo Sekihara, Kazuhito Funai, Kazuma Masumoto, Kazuya Shinmura · 2026
Read Keratin 1 and keratin 18 as immunohistochemical markers for distinguishing pulmonary metastases of oral squamous cell carcinoma from primary lung squamous cell carcinoma by Yoshiko Watanabe, Hisami Kato, Rei Ishikawa, Kimio Yoshimura, Hidetaka Yamada, Ryosuke Miyazaki, Sayuri Takeuchi, S M Jahurul Haque, Katsuhiro Yoshimura, Yasuhiro Sakai, Miki Sugita, Yusuke Inoue, Yusuke Takanashi, Keigo Sekihara, Kazuhito Funai, Kazuma Masumoto, Kazuya Shinmura (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13369157.txt.
Description
Yoshiko Watanabe and co-authors test two protein markers that can tell apart look-alike cancers, in a 2026 study. Mouth cancer can spread to the lungs, where it mimics a lung cancer that starts there. Telling the two apart guides treatment, but routine lab markers are scarce. The team screened public gene data for candidates.
Two keratin proteins stood out across tissue samples from both cancer types. Keratin 1 appeared mainly in the mouth cancer cases and rarely in lung ones. Keratin 18 showed the mirror pattern. Both markers sorted the cancers with high accuracy in lab staining tests. In matched pairs confirmed by full gene reads, the pattern held. Pathologists gain a practical pair of stains for a hard call.
Catalog record
| CREATOR | Yoshiko Watanabe, Hisami Kato, Rei Ishikawa, Kimio Yoshimura, Hidetaka Yamada, Ryosuke Miyazaki, Sayuri Takeuchi, S M Jahurul Haque, Katsuhiro Yoshimura, Yasuhiro Sakai, Miki Sugita, Yusuke Inoue, Yusuke Takanashi, Keigo Sekihara, Kazuhito Funai, Kazuma Masumoto, Kazuya Shinmura |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |