Cellular and molecular basis of PfCoronin function in artemisinin resistance in Plasmodium falciparum
Imran Ullah, Madeline A. Farringer, Malhar Khushu, Anna Y. Burkhard, Erica Hathaway, Bailey C. Willett, Sara H. Shin, Aabha I. Sharma, River Mallick, Eva S. Istvan, Morgan C. Martin, Oliver Harrigan, Kairon L. Shao, Jeffrey D. Dvorin, Daniel L. Hartl, Sarah K. Volkman, Selina Bopp, Sabrina Absalon, · 2026
Read Cellular and molecular basis of PfCoronin function in artemisinin resistance in Plasmodium falciparum by Imran Ullah, Madeline A. Farringer, Malhar Khushu, Anna Y. Burkhard, Erica Hathaway, Bailey C. Willett, Sara H. Shin, Aabha I. Sharma, River Mallick, Eva S. Istvan, Morgan C. Martin, Oliver Harrigan, Kairon L. Shao, Jeffrey D. Dvorin, Daniel L. Hartl, Sarah K. Volkman, Selina Bopp, Sabrina Absalon, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13365827.txt.
Description
Imran Ullah leads a large team that pins down how a malaria parasite protein helps the parasite resist artemisinin drugs, in a study published in two thousand twenty-six. These drugs anchor malaria care worldwide, so resistance is a grave threat. Changes in the protein PfCoronin had been tied to treatment failure, but how they worked was unclear.
The team found that PfCoronin binds actin and sits at the parasite's surface, at its food sac, and in small sacs that carry host cell material. Mutant forms sit in the wrong places and upset actin balance. Young parasites then take in less host cell content, hence less hemoglobin. With less hemoglobin broken down, less of the drug gets switched on inside the parasite. The authors see this shared uptake path as a core trick of resistance.
Catalog record
| CREATOR | Imran Ullah, Madeline A. Farringer, Malhar Khushu, Anna Y. Burkhard, Erica Hathaway, Bailey C. Willett, Sara H. Shin, Aabha I. Sharma, River Mallick, Eva S. Istvan, Morgan C. Martin, Oliver Harrigan, Kairon L. Shao, Jeffrey D. Dvorin, Daniel L. Hartl, Sarah K. Volkman, Selina Bopp, Sabrina Absalon, |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |