Metabolism meets immunity: TCA-cycle activation protects the vulnerable newborn
Tineke Vanderhaeghen, Claude Libert, Jolien Vandewalle · 2026
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Description
Tineke Vanderhaeghen and others discussed how TCA-cycle switch-on protects at risk newborns, in 2026. Preterm neonates are highly susceptible to sickness that easily become sepsis, a major global burden with hard finding and care limited to drugs and supportive care. How newborn defence interacts with energy use during illness was poorly known.
In the same issue, Wu and others showed a clear link between body-wide energy use and neonatal defence, identifying tricarboxylic acid cycle metabolites as key regulators linked with reduced illness burden. The commentary places that finding in context for neonatal care. Doctors gain a energy perspective on newborn illness that may eventually yield adjunct care.
Catalog record
| CREATOR | Tineke Vanderhaeghen, Claude Libert, Jolien Vandewalle |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 11 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |