BAI adhesion-GPCRs perform distinct functions in neural development differentially controlled by RTN4R and C1ql ligands
Jie Wang, Jinzhao Wang, Yi Miao, Yang Li, Shaoyuan Zhu, Yu Zhang, Ahmed Yousif, Min Huang, Marius Wernig, Thomas C. Südhof · 2025
Read BAI adhesion-GPCRs perform distinct functions in neural development differentially controlled by RTN4R and C1ql ligands by Jie Wang, Jinzhao Wang, Yi Miao, Yang Li, Shaoyuan Zhu, Yu Zhang, Ahmed Yousif, Min Huang, Marius Wernig, Thomas C. Südhof (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13365561.txt.
Description
Wang and co-authors sort out what three related brain receptors each do as neurons grow. The receptors, named BAI1, BAI2, and BAI3, sit on cell surfaces and catch two families of partner proteins. Using mouse hippocampal cultures, gene knockouts, and rescue tests, the 2025 study compares the three side by side.
Deleting BAI1 or BAI3 made branches grow bushier but cut the number of excitatory connection points, while deleting BAI2 changed little. Only BAI3 catches both partner families. Rescue tests showed one partner family must bind for BAI3 to rein in branching and build connections, while the other is needed only to organize connections. The authors conclude the receptors divide labor in shaping young neurons.
Catalog record
| CREATOR | Jie Wang, Jinzhao Wang, Yi Miao, Yang Li, Shaoyuan Zhu, Yu Zhang, Ahmed Yousif, Min Huang, Marius Wernig, Thomas C. Südhof |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 103 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |