PAMP orchestrates proline metabolic rewiring to suppress LUAD via PYCR1 inhibition
Yun Ma, Jiani Yi, Chengcai Zheng, Juze Yang, Jia Li, Mengqian Yu, Xinyi Qian, Jiayi Ren, Xiaofan Wu, Yan Lu, Pengyuan Liu · 2026
Read PAMP orchestrates proline metabolic rewiring to suppress LUAD via PYCR1 inhibition by Yun Ma, Jiani Yi, Chengcai Zheng, Juze Yang, Jia Li, Mengqian Yu, Xinyi Qian, Jiayi Ren, Xiaofan Wu, Yan Lu, Pengyuan Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13365495.txt.
Description
Yun Ma and others found a micropeptide, PAMP, that suppresses lung adenocarcinoma by rewiring proline energy use, in 2026. Long non-coding RNAs can encode working micropeptides through small open reading frames, reshaping views of the supposedly non-coding genome. A forty-eight-amino-acid peptide encoded by PSMA3-AS1 emerged as a choice tumour suppressor.
PAMP was much downregulated in lung adenocarcinoma tissues and correlated with favourable prognosis. Working assays showed it inhibits cancer cell proliferation in vitro and suppresses tumour growth in vivo, acting through inhibition of PYCR1 and proline energy rewiring. Cancer teams gain a novel micropeptide way with healing power in lung adenocarcinoma.
Catalog record
| CREATOR | Yun Ma, Jiani Yi, Chengcai Zheng, Juze Yang, Jia Li, Mengqian Yu, Xinyi Qian, Jiayi Ren, Xiaofan Wu, Yan Lu, Pengyuan Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |