Ca2+ trapping by allosteric coupling explains species differences in TRPM2 inactivation reversibility
Adam Bartok, László Csanády · 2026
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Description
Adam Bartok and László Csanády explain, in a 2026 study, why a heat-sensing channel in human cells switches off for good while its fish twin does not. The channel, TRPM2, helps the brain track body temperature. It opens when calcium and a second signal bind, but a separate gate shuts it after long exposure, and in humans that shut state seemed permanent.
Working with the zebrafish version, where the shut state reverses easily, the team used electrical measures and modelling to find the cause. The shut gate traps calcium in its binding site. Human channels grip that calcium so tightly in the shut state that escape needs calcium levels far below anything cells reach. The work maps how this trait evolved in vertebrates.
Catalog record
| CREATOR | Adam Bartok, László Csanády |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |