O-GlcNAcylation reprograms microglial inflammatory states and attenuates Alzheimer’s disease pathology
Dong Yeol Kim, Sang-Min Kim, Chanhaeng Lee, Inn-Oc Han · 2026
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Description
Dong Yeol Kim and three colleagues present a 2026 study on a sugar-based protein coating that may calm brain inflammation in Alzheimer's disease. The coating, called O-GlcNAcylation, tunes how proteins behave under stress. In Alzheimer's, the brain's immune cells, microglia, lean toward an aggressive state that harms neurons.
The team found the coating sharply reduced in patient hippocampus tissue, alongside stronger inflammatory signaling. In mouse and cell models of inflammation, the coating fell as microglia turned aggressive. Feeding glucosamine restored the coating, quieted the inflammatory switches, and shifted microglia toward a calmer state. Treated mice also kept their memory and neurons better. The authors propose raising this coating as a fresh treatment strategy.
Catalog record
| CREATOR | Dong Yeol Kim, Sang-Min Kim, Chanhaeng Lee, Inn-Oc Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |