ANXA11 suppression restores muscular function in the mdx mouse model of Duchenne muscular dystrophy (DMD)
Wen Tang, Bowen Lin, Ming Jin, Tianzhen Liu, Jingyi Zhou, Yanhong Jin, Yi Chen, Yanan Zhu, Gonglu Liu, Ping Hu, Chengyong Shen, Zhuoxian Meng, Guoping Peng, Liqun Lei, Xingxu Huang, Chenxiao Zhang, Ke Chen, Guiheng Zhang, Xufeng Yang, Xue Lv, Adrien Rousseau, Jian Yang, Zhi-Ying Wu, Ge Bai, Zhen Zho · 2026
Read ANXA11 suppression restores muscular function in the mdx mouse model of Duchenne muscular dystrophy (DMD) by Wen Tang, Bowen Lin, Ming Jin, Tianzhen Liu, Jingyi Zhou, Yanhong Jin, Yi Chen, Yanan Zhu, Gonglu Liu, Ping Hu, Chengyong Shen, Zhuoxian Meng, Guoping Peng, Liqun Lei, Xingxu Huang, Chenxiao Zhang, Ke Chen, Guiheng Zhang, Xufeng Yang, Xue Lv, Adrien Rousseau, Jian Yang, Zhi-Ying Wu, Ge Bai, Zhen Zho (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13365423.txt.
Description
Wen Tang and co-authors find a gene that holds back muscle repair in a mouse model of Duchenne muscular dystrophy, in work from 2026. In this disease, a missing protein leads to steady muscle loss. The team asked whether other controls also block repair beyond that loss.
Joining protein and single-cell gene data, they found the gene ANXA11 switched up in young repair fibers of both mice and patients. That rise stalled fiber growth through a growth signal path. Turning the gene off, by breeding or by a virus-carried tool, let fibers mature and restored muscle function in the mice. The authors name the gene as a fresh drug target for the disease.
Catalog record
| CREATOR | Wen Tang, Bowen Lin, Ming Jin, Tianzhen Liu, Jingyi Zhou, Yanhong Jin, Yi Chen, Yanan Zhu, Gonglu Liu, Ping Hu, Chengyong Shen, Zhuoxian Meng, Guoping Peng, Liqun Lei, Xingxu Huang, Chenxiao Zhang, Ke Chen, Guiheng Zhang, Xufeng Yang, Xue Lv, Adrien Rousseau, Jian Yang, Zhi-Ying Wu, Ge Bai, Zhen Zho |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |