LCAL4–FUS cooperation switches on MMP13 and drives osteolytic bone metastasis in breast cancer
Qiji Li, Mingjian Fan, Xiaoting Sun, Xiaoying Yang, Yuhao Zhang, Zihan Zheng, Xuan Zhang, Xian Zhang, Qingqing Zhu, Zhenchong Xiong, Kefeng Lei, Chengming Zhu, Qin Tian, Yun Wang, Meng Wang, Liping Ye · 2026
Read LCAL4–FUS cooperation switches on MMP13 and drives osteolytic bone metastasis in breast cancer by Qiji Li, Mingjian Fan, Xiaoting Sun, Xiaoying Yang, Yuhao Zhang, Zihan Zheng, Xuan Zhang, Xian Zhang, Qingqing Zhu, Zhenchong Xiong, Kefeng Lei, Chengming Zhu, Qin Tian, Yun Wang, Meng Wang, Liping Ye (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13364713.txt.
Description
Qiji Li and co-workers pin in 2026 a gene chain that drives breast cancer spread to bone, where it eats bone away. A long non code RNA, named LCAL4, runs high in bone spread tumors and marks poor life odds. Cell and mouse tests show it drives the spread.
The RNA acts as a frame that brings a partner protein to a bone eat gene and turns it on. The gene's output wakes bone eat cells, and freed bone growth cues feed the tumor in a loop. Cuts to the chain stopped bone spread in mice. The chain is a clear drug aim.
Catalog record
| CREATOR | Qiji Li, Mingjian Fan, Xiaoting Sun, Xiaoying Yang, Yuhao Zhang, Zihan Zheng, Xuan Zhang, Xian Zhang, Qingqing Zhu, Zhenchong Xiong, Kefeng Lei, Chengming Zhu, Qin Tian, Yun Wang, Meng Wang, Liping Ye |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49238 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |