Multifunctional 3D-Printed Polylactic Acid/Hydroxyapatite Systems for Cranial Applications: Functionalization and Local Anti-Inflammatory Drug Delivery
Alessia D’Andrea, Sara Biesuz, Elena Mazzinelli, Giuseppina Nocca, Ilaria Cacciotti · 2026
Read Multifunctional 3D-Printed Polylactic Acid/Hydroxyapatite Systems for Cranial Applications: Functionalization and Local Anti-Inflammatory Drug Delivery by Alessia D’Andrea, Sara Biesuz, Elena Mazzinelli, Giuseppina Nocca, Ilaria Cacciotti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13363988.txt.
Description
Alessia D'Andrea and colleagues present a 2026 study on 3D-printed skull implants that also deliver medicine. After brain injury, cranial plates must shield the brain, bond with bone, and avoid swelling and infection. Their porous polylactic acid scaffolds, printed layer by layer, carry a hydroxyapatite coating that invites bone growth, plus tiny plastic beads loaded with the anti-inflammatory drug dexamethasone tucked inside.
A base wash before coating made the mineral layer even and firmly held. Coated scaffolds raised cell survival and bone-forming behavior in dishes, and the drug beads released their load in a controlled way without poisoning cells. The authors present the combined implant as a step toward one-piece cranial repair with local therapy built in.
Catalog record
| CREATOR | Alessia D’Andrea, Sara Biesuz, Elena Mazzinelli, Giuseppina Nocca, Ilaria Cacciotti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59664 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |