Scutellaria baicalensis Extract Protects Against Cerebral Ischemia-Reperfusion Injury in Male Rats by Inhibiting Ferroptosis via the PI3K/AKT Pathway
Mengxuan Zhang, Xueao Chen, Chenhuan Shentu, Dongdong Jin, Jiaying Zhu, Chendao Ruan, Mingjiang Mao, Xiaofeng Yuan · 2026
Read Scutellaria baicalensis Extract Protects Against Cerebral Ischemia-Reperfusion Injury in Male Rats by Inhibiting Ferroptosis via the PI3K/AKT Pathway by Mengxuan Zhang, Xueao Chen, Chenhuan Shentu, Dongdong Jin, Jiaying Zhu, Chendao Ruan, Mingjiang Mao, Xiaofeng Yuan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13363625.txt.
Description
Mengxuan Zhang and colleagues report a 2026 rat study on an extract of Scutellaria baicalensis, a skullcap herb long used for stroke, against brain injury after blood flow returns. This ischemia-reperfusion injury kills brain cells in part through ferroptosis, an iron-driven cell death. The team blocked the main brain artery in rats, treated them with the extract, and probed tissue with protein maps, stains, and cell tests.
Treated rats scored better on nerve function and showed less brain damage. Iron buildup and power-unit harm in cells fell, and a key protective axis recovered. Blocking the PI3K/AKT pathway erased the benefit, in animals and in cells, which pins the effect to that path. Four active compounds were found absorbed in the blood.
Catalog record
| CREATOR | Mengxuan Zhang, Xueao Chen, Chenhuan Shentu, Dongdong Jin, Jiaying Zhu, Chendao Ruan, Mingjiang Mao, Xiaofeng Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46489 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |