Chondroitin sulfate reinforces mitochondrial redox homeostasis to enable integrated intervertebral disc regeneration
Xin Wang, Yixue Huang, Yilin Yang, Yesheng Jin, Yun Xiao, Hao Liu, Yong Xu, Yijie Liu · 2026
Read Chondroitin sulfate reinforces mitochondrial redox homeostasis to enable integrated intervertebral disc regeneration by Xin Wang, Yixue Huang, Yilin Yang, Yesheng Jin, Yun Xiao, Hao Liu, Yong Xu, Yijie Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13363253.txt.
Description
Xin Wang and colleagues present a 2026 study on chondroitin sulfate, a building block of cartilage, as a dual-action treatment for worn spinal discs. Disc wear drives much low back pain through cell stress, failing power units in cells, and matrix breakdown. In disc cells from both the outer ring and the soft core, the compound boosted antioxidant defenses and matrix building through a named signaling path.
The team then loaded it into an injectable gel of PVA and collagen that firms up the disc while it delivers the drug. In rats with disc damage, the gel kept disc height and scan brightness, restored the two-part structure, and raised matrix and antioxidant marks. The authors pitch the combined gel as a unified repair strategy.
Catalog record
| CREATOR | Xin Wang, Yixue Huang, Yilin Yang, Yesheng Jin, Yun Xiao, Hao Liu, Yong Xu, Yijie Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66021 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |