Chirality Transfer and Thiazolidine or Thiazine Formation in Reactions of L and D Enantiomers of β- or γ-Sulfhydryl Amino Acids with Imidazole Carboxaldehydes and Nickel(II)
Cynthia T. Brewer, Greg Brewer, Raymond J. Butcher · 2026
Read Chirality Transfer and Thiazolidine or Thiazine Formation in Reactions of L and D Enantiomers of β- or γ-Sulfhydryl Amino Acids with Imidazole Carboxaldehydes and Nickel(II) by Cynthia T. Brewer, Greg Brewer, Raymond J. Butcher (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13363088.txt.
Description
Cynthia T Brewer, Greg Brewer, and Raymond J Butcher present a 2026 chemistry study on how handedness passes through a family of nickel complexes. They reacted left- and right-handed forms of three sulfur-bearing amino acids with an imidazole aldehyde and nickel salts. Each reaction closed a new ring, thiazolidine or thiazine, and yielded just one mirror form of product, which they confirmed with crystal structures and standard spectra.
The starting amino acid kept its handedness, and the two new centers formed with matched settings in the five-membered rings. In the six-membered ring case, the new centers matched each other but opposed the old one, yet all key hydrogen atoms stayed on the same face. The authors credit the fused ring frame for this strict order.
Catalog record
| CREATOR | Cynthia T. Brewer, Greg Brewer, Raymond J. Butcher |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23842 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |