Cationic Amphiphiles with Five-Membered Heterocyclic Linkers: Synthesis, Self-Assembly, and DNA Complexation Properties
Anda Sipola, Ksenija Korotkaja, Karlis Pajuste, Aiva Plotniece, Arkadij Sobolev · 2026
Read Cationic Amphiphiles with Five-Membered Heterocyclic Linkers: Synthesis, Self-Assembly, and DNA Complexation Properties by Anda Sipola, Ksenija Korotkaja, Karlis Pajuste, Aiva Plotniece, Arkadij Sobolev (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13362763.txt.
Description
Anda Sipola and colleagues report a 2026 chemistry study on fat-like carrier molecules designed to ferry DNA into cells. Such carriers could deliver gene therapies without using viruses, but their shape decides how well they work. The team built new carriers whose middle link is a five-membered ring, using pyrrole, furan, or thiophene, and compared them with plain chain-linked versions.
The ring-linked carriers folded into bubbles that wrapped up more than 80 percent of the test DNA at the best mixing ratios, far better than the plain versions. Particle sizes varied widely, yet the pattern was clear: the ring link strongly shaped both assembly and DNA grip. The results give gene delivery designers a fresh building block to test in cells next.
Catalog record
| CREATOR | Anda Sipola, Ksenija Korotkaja, Karlis Pajuste, Aiva Plotniece, Arkadij Sobolev |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38096 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |