Polyporusterone E, a Key Component of Polyporus umbellatus, as a Potential Regulator of CHEK 1 in Liver Cancer: Integrated Network Pharmacology, Bioinformatics, and Experimental Validation
Xinhui Huang, Ruichen Gao, Xinran Yu, Zheng Feng, Qingxia Wang, Xiaotian Wu, Shulu Zhang, Yinze Zhong, Yeqing Xu, Meiting Jiang, Chunli Gan, Xiaotong Wang, Shuang Jiang, Chunjuan Yang · 2026
Read Polyporusterone E, a Key Component of Polyporus umbellatus, as a Potential Regulator of CHEK 1 in Liver Cancer: Integrated Network Pharmacology, Bioinformatics, and Experimental Validation by Xinhui Huang, Ruichen Gao, Xinran Yu, Zheng Feng, Qingxia Wang, Xiaotian Wu, Shulu Zhang, Yinze Zhong, Yeqing Xu, Meiting Jiang, Chunli Gan, Xiaotong Wang, Shuang Jiang, Chunjuan Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13362459.txt.
Description
Xinhui Huang and a large team report a 2026 study on a fungus used in Chinese medicine and its possible role against liver cancer. Using computer maps of drug targets plus lab tests, they picked out the fungus compound most likely to matter, a sterol called polyporusterone E. The trail led to CHEK1, a gene that helps cancer cells grow and that marks a poor outlook when overactive.
Computer runs showed the compound binds CHEK1 in a stable way. In liver cancer cells, the fungus extract and the pure compound cut cell growth and lowered CHEK1 levels. Extra CHEK1 sped cell growth and spread, while silencing it did the reverse. The work gives early support for the compound as an add-on worth more study.
Catalog record
| CREATOR | Xinhui Huang, Ruichen Gao, Xinran Yu, Zheng Feng, Qingxia Wang, Xiaotian Wu, Shulu Zhang, Yinze Zhong, Yeqing Xu, Meiting Jiang, Chunli Gan, Xiaotong Wang, Shuang Jiang, Chunjuan Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57582 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |