LncRNA GAS5 inhibits the remodeling of the tumor microenvironment by binding to miR-93-5p, thereby suppressing the development of osteosarcoma
Tianbo Zhu, Xiaokang Zhu, You Zhou, Wenyao Chen, Wei Huang, Yafeng Lv, Xiangyong Que, Yi Li, Qingsong Tian, Mireadeli Abulimiti, Xinzhi Li · 2026
Read LncRNA GAS5 inhibits the remodeling of the tumor microenvironment by binding to miR-93-5p, thereby suppressing the development of osteosarcoma by Tianbo Zhu, Xiaokang Zhu, You Zhou, Wenyao Chen, Wei Huang, Yafeng Lv, Xiangyong Que, Yi Li, Qingsong Tian, Mireadeli Abulimiti, Xinzhi Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13362224.txt.
Description
A long non-coding RNA that slows bone cancer growth is studied by Zhu and co-authors in a 2026 paper. Such RNAs do not build proteins, but they can tune other genes. In bone cancer cells, the RNA studied here was low, while a small partner RNA was high, hinting at a linked pair.
Lab work shows the long RNA soaks up the small partner, which frees a protective protein to rise. That protein speeds the breakdown of a key alarm protein, so swelling signals fall. With the alarm muted, tumors grew less in the tests. The authors present the chain as a fresh drug target for a cancer that often hits young people.
Catalog record
| CREATOR | Tianbo Zhu, Xiaokang Zhu, You Zhou, Wenyao Chen, Wei Huang, Yafeng Lv, Xiangyong Que, Yi Li, Qingsong Tian, Mireadeli Abulimiti, Xinzhi Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |