Paeonol-Loaded PLGA Nanoparticles Attenuate DMH-Induced Colorectal Carcinogenesis-Associated Oxidative Stress, Inflammation, and Cellular Dysregulation via Modulation of NRF2/HO-1 Signaling in Rats
M. Alfawaz, Ekramy M. Elmorsy, Ahmad Najem Alshammari, Eida M. Alshammari, Mai A. Salem, Gehad E. Elshopakey, Manal S. Fawzy, Nagwa M. Aly · 2026
Read Paeonol-Loaded PLGA Nanoparticles Attenuate DMH-Induced Colorectal Carcinogenesis-Associated Oxidative Stress, Inflammation, and Cellular Dysregulation via Modulation of NRF2/HO-1 Signaling in Rats by M. Alfawaz, Ekramy M. Elmorsy, Ahmad Najem Alshammari, Eida M. Alshammari, Mai A. Salem, Gehad E. Elshopakey, Manal S. Fawzy, Nagwa M. Aly (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13361842.txt.
Description
M Alfawaz and co-authors tested a plant compound in tiny carriers against colon cancer in rats in a 2026 study. Paeonol, from peony root, fights oxidative stress and inflammation, two drivers of colorectal cancer. The team loaded it into biodegradable nanoparticles to help it reach tissue. Sixty male rats were split into six groups, including healthy controls and groups given a cancer-triggering chemical for ten weeks.
Some triggered rats got plain paeonol, others the nanoparticle form. Blood markers of tumors, stress, and inflammation were measured, along with gene activity for cell death and clean-up paths. Tissue from colon, liver, and kidney was examined closely. The focus was a protective pathway called NRF2/HO-1. Better delivery could turn a promising plant compound into a real shield.
Catalog record
| CREATOR | M. Alfawaz, Ekramy M. Elmorsy, Ahmad Najem Alshammari, Eida M. Alshammari, Mai A. Salem, Gehad E. Elshopakey, Manal S. Fawzy, Nagwa M. Aly |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57331 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |