Factors Affecting Vancomycin and Piperacillin–Tazobactam-Induced Nephrotoxicity
Mollie VanNatta Day, Ruhul Munshi, Kalyn Picard, Alexandre E. Malek · 2026
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Description
Mollie VanNatta Day and co-authors studied kidney harm from a common antibiotic pair in a 2026 paper. Vancomycin plus piperacillin-tazobactam is a workhorse duo for serious infections, but whether the pair itself injures kidneys has been hotly debated. The team reviewed adults at their academic hospital who got both drugs for at least 48 hours between May 2019 and March 2023. In all, 350 patients qualified.
Kidney injury struck 89 patients, about a quarter of the group. The team compared those harmed with those spared across many traits: other kidney-stressing drugs, infection site, blood pressure support, treatment length, and drug levels in blood. Sorting the true risk factors helps doctors weigh this useful pair against safer but sometimes weaker options, and to watch the right patients more closely.
Catalog record
| CREATOR | Mollie VanNatta Day, Ruhul Munshi, Kalyn Picard, Alexandre E. Malek |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25742 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |