Sirtuins at the Interface of Glucose Metabolism, Diabetes, and Heart Failure: Metabolic Sensing in Cardiometabolic Disease
Jan Krekora, Jarosław Drożdż, Elzbieta Pawlowska, Janusz Blasiak · 2026
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Description
Jan Krekora and co-authors review a family of proteins that sense fuel use in the failing diabetic heart in a 2026 paper. Heart failure with diabetes forms a distinct pattern, marked by poor sugar use in heart muscle and weak cell power plants. The proteins, called sirtuins, depend on a helper molecule named NAD+ to work. They coordinate how the heart burns fuel and answers stress.
In animal and cell studies, sirtuin loss, often from drained NAD+, made heart metabolism stiff and wasteful. Restoring NAD+ or sirtuin action improved power plant efficiency and coordination. Human tissue and blood marker studies back the story, though mostly by association, not proof of cause. The review weighs sirtuins as drug targets for a common and deadly pairing of diseases.
Catalog record
| CREATOR | Jan Krekora, Jarosław Drożdż, Elzbieta Pawlowska, Janusz Blasiak |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54670 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |