Mechanistic Role of Sestrin2 in Exercise-Mediated Cardioprotection Against Obesity-Related Cardiomyopathy
Meili Hao, Wanyu Zhu, Li Zhao, Wenyan Bo · 2026
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Description
Meili Hao and co-authors studied how exercise shields the obese heart in a 2026 mouse study. Exercise is a safe way to improve obesity and its harm, but the inner mechanism is not fully mapped. The team focused on sestrin2, a stress-guard protein. Male mice were fattened on a high-fat diet and then put through aerobic training.
Heart scans and tissue stains showed how much the training eased heart damage. In dish tests with rat heart cells, fat exposure harmed the cells, and adding sestrin2 let the team probe its role. They tracked damage, scarring, inflammation, and oxidative stress, plus a key energy signal path. The work aims to explain, step by step, how moving the body protects the heart in obesity.
Catalog record
| CREATOR | Meili Hao, Wanyu Zhu, Li Zhao, Wenyan Bo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27657 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |