RNF126 in Physiology and Disease: A Multifunctional RING-Type E3 Ubiquitin Ligase in Protein Homeostasis, DNA Repair, and Cancer
Anh Duc Vu, Shiori Mori, Takeharu Sakamoto · 2026
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Description
Anh Duc Vu and co-authors review a versatile protein in a 2026 paper. RNF126 is an enzyme that tags other proteins with ubiquitin, a small label that can order a protein's destruction or change its job. Working with helper proteins, it clears misplaced and misfolded proteins, keeping the cell's protein stock healthy. It also helps repair damaged DNA through several partners.
Beyond housekeeping, the protein supports embryo growth and male fertility, and many cancers exploit it to grow faster. The review gathers these roles and the tumor-driving tricks the protein performs. Such a hub, with one clear working part, draws interest as a possible drug target.
Catalog record
| CREATOR | Anh Duc Vu, Shiori Mori, Takeharu Sakamoto |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48907 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |