Analytical Performance of the Avida Duo Assay for Simultaneous Mutation and Methylation Profiling in Circulating Cell-Free DNA
Russell J. Diefenbach, Ashleigh Stewart, Wei Yen Chan, Suzanah C. Boyd, Alexander M. Menzies, Georgina V. Long, Helen Rizos · 2026
Read Analytical Performance of the Avida Duo Assay for Simultaneous Mutation and Methylation Profiling in Circulating Cell-Free DNA by Russell J. Diefenbach, Ashleigh Stewart, Wei Yen Chan, Suzanah C. Boyd, Alexander M. Menzies, Georgina V. Long, Helen Rizos (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13359521.txt.
Description
Russell J. Diefenbach and co-authors test a two-in-one blood test for cancer in a 2026 study. Tumors shed DNA into the blood, and reading it can reveal both gene mutations and chemical methylation tags that mark cancer. The Avida Duo assay reads both from one sample of this floating DNA. The team checked its performance in patients with advanced melanoma.
Using plasma from two separate patient groups, they tuned the workflow for steadier output and sharper mutation detection. Methylation results matched a rival established assay closely. A single sensitive test for both signal types could simplify how doctors detect cancer, track it, and pick treatment.
Catalog record
| CREATOR | Russell J. Diefenbach, Ashleigh Stewart, Wei Yen Chan, Suzanah C. Boyd, Alexander M. Menzies, Georgina V. Long, Helen Rizos |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31496 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |