Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor
Isaac W Babcock, Sydney A Labuzan, Abigail G Kelly, Anne E Schuster, Seblework Alemu, Lydia A Sibley, Anne E Marchildon, Tajie H Harris · 2026
Read Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor by Isaac W Babcock, Sydney A Labuzan, Abigail G Kelly, Anne E Schuster, Seblework Alemu, Lydia A Sibley, Anne E Marchildon, Tajie H Harris (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13359089.txt.
Description
Isaac W Babcock and others helped the truth of brain cells genetic aiming at using a CSF1R blocker, in 2026. Brain cells, the brain's local white cells, are central to brain immunity, but aiming at them by genes is hard because widely used Cre lines also affect outer white cells. Those outer cells fail to turn over within the standard four-week window meant to improve truth.
The team joined tamoxifen start in Cx3cr1CreERT2 mice with CSF1R blocker care to deplete outer white cells while keeping brain-cell aiming at. The joined approach helped truth without losing brain-cell tagging. Neuroscientists gain a useful method for attributing experimental effects to brain cells rather than to outer immune cells.
Catalog record
| CREATOR | Isaac W Babcock, Sydney A Labuzan, Abigail G Kelly, Anne E Schuster, Seblework Alemu, Lydia A Sibley, Anne E Marchildon, Tajie H Harris |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |