Differential DNA methylation in blood as potential mediator of the association between ambient PM2.5 and cerebrospinal fluid biomarkers of Alzheimer’s disease among a cognitively normal population-based cohort
Tszshan Ma, Jiaqi Liu, Donghai Liang, Stefanie Ebelt, Kyle Steenland, Allan I Levey, James J Lah, Aliza P Wingo, Thomas S Wingo, Anke Hüls · 2026
Read Differential DNA methylation in blood as potential mediator of the association between ambient PM2.5 and cerebrospinal fluid biomarkers of Alzheimer’s disease among a cognitively normal population-based cohort by Tszshan Ma, Jiaqi Liu, Donghai Liang, Stefanie Ebelt, Kyle Steenland, Allan I Levey, James J Lah, Aliza P Wingo, Thomas S Wingo, Anke Hüls (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13358818.txt.
Description
Tszshan Ma and co-authors study how air pollution may reach the brain in a 2026 paper. Fine particles in dirty air, called PM2.5, raise the risk of Alzheimer's disease, and their effects show up in spinal fluid years before symptoms. The team asked whether chemical tags on DNA in blood form a link in that chain.
They studied 536 cognitively normal adults in a brain health study, estimating each person's yearly particle exposure at home. Genome-wide DNA tag patterns in blood were tested as go-betweens for spinal fluid markers of Alzheimer's. Finding such a path could reveal early warning signs and points where the harm might be blocked.
Catalog record
| CREATOR | Tszshan Ma, Jiaqi Liu, Donghai Liang, Stefanie Ebelt, Kyle Steenland, Allan I Levey, James J Lah, Aliza P Wingo, Thomas S Wingo, Anke Hüls |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54304 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |