Leveraging the perioperative window in pancreatic cancer: lessons from the PROSPER trial
Forrest Bethel, Andres Corona, Peter Hosein, Jashodeep Datta · 2026
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Description
Forrest Bethel and co-authors wrote a 2026 commentary on pancreatic cancer, one of the deadliest cancers. Even after full surgery and strong drug treatment, the cancer almost always returns, often in distant organs. The authors focus on the days around surgery, a window they argue is not neutral for the body.
Surgery stirs stress hormones, inflammation, and a brief dip in the immune cells that kill stray cancer cells. The PROSPER trial tested whether drugs given in this window can protect patients while leftover cancer is at its weakest. Bethel and co-authors draw lessons from that work for how future trials and care should be timed.
Catalog record
| CREATOR | Forrest Bethel, Andres Corona, Peter Hosein, Jashodeep Datta |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12009 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |