Adaptable Covalent Organic Framework‐Hydrogel Microneedles for Glucose‐Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy
Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang · 2026
Read Adaptable Covalent Organic Framework‐Hydrogel Microneedles for Glucose‐Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy by Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13356551.txt.
Description
Menghan Zhou and co-authors built a glucose-responsive microneedle patch in 2026 to treat diabetic wounds, which often stall in a state of lasting inflammation. The patch carries a plant compound, isoliquiritigenin, tied into a framework that releases it when sugar is high. The needles push the drug deep into skin, past the surface barrier.
In lab tests, the system released drug under high sugar, calmed inflammation, and mopped up harmful oxygen particles by targeting an immune sensor called ZBP1. In diabetic mice, the patch steadied inflammation and drove full-thickness wound healing with new collagen. The authors present it as a promising path for clinic use.
Catalog record
| CREATOR | Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59996 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |