AAV-norrin gene therapy rescues retinal defects in mice with Norrie disease and oxygen-induced retinopathy
Andrea E Dillinger, Herbert Jaegle, Holger Fuchs, Benjamin Strobel, Norbert Redemann, Ernst R Tamm · 2026
Read AAV-norrin gene therapy rescues retinal defects in mice with Norrie disease and oxygen-induced retinopathy by Andrea E Dillinger, Herbert Jaegle, Holger Fuchs, Benjamin Strobel, Norbert Redemann, Ernst R Tamm (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13355717.txt.
Description
Andrea E Dillinger and co-authors tested gene therapy in 2026 in mice that lack norrin, a signal needed to grow blood vessels in the retina. Without it, mice and humans develop poor retinal vessels and blindness, as in Norrie disease. The team injected two virus types carrying the norrin gene into the eyes of young mice.
Both virus types fully restored capillary growth in the retina, kept its barrier sound, and rescued vision in the mutant mice. In a model of oxygen injury like that seen in premature babies, the therapy cut vessel loss and harmful new growth. The authors see promise for Norrie disease and related eye conditions.
Catalog record
| CREATOR | Andrea E Dillinger, Herbert Jaegle, Holger Fuchs, Benjamin Strobel, Norbert Redemann, Ernst R Tamm |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55543 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |