Mitochondrial permeability transition in redox homeostasis and ferroptosis
Lishu Guo · 2026
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Description
Lishu Guo reviews in 2026 how a process in mitochondria, the cell's powerhouses, acts as a switch for cell stress and death. The process, called mitochondrial permeability transition, opens pores that can either guard the cell or amplify harmful oxygen signals. It is tightly linked to ferroptosis, a form of cell death driven by iron and fat damage.
At low levels, oxygen signals help cells adapt and survive, but excess levels damage fats, proteins, and DNA. Recent work shows two mitochondrial parts working together to coordinate pore opening. The review maps how the switch flips between defense and death, with clues for future treatments.
Catalog record
| CREATOR | Lishu Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56887 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |