Linalool targets NR3C2 to inhibit NF-κB-mediated gastric cancer progression
Ying Hu, Shunfeng Chen, Yu Wang, Ling Liu, Chaoyi Zhang, Hong Chen, Yuanyuan Duanmu, Zhaotian Su, Jun Ma · 2026
Read Linalool targets NR3C2 to inhibit NF-κB-mediated gastric cancer progression by Ying Hu, Shunfeng Chen, Yu Wang, Ling Liu, Chaoyi Zhang, Hong Chen, Yuanyuan Duanmu, Zhaotian Su, Jun Ma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13352738.txt.
Description
Ying Hu and eight co-authors present a 2026 study on linalool, a fragrant plant compound, against stomach cancer. The team tested it on cancer cells and on tumors grown in mice. Linalool slowed the cells' growth, movement, and invasion, and shrank the transplanted tumors. Tracing its target, they found it binds and stabilizes a protein called NR3C2, sparing it from the cell's disposal machinery.
That protein switches on a second gene, NFKBIZ, which in turn damps the NF-κB pathway, a driver of inflammation and cancer growth. Removing NR3C2 partly undid linalool's benefit, confirming the chain. In patient samples, both proteins ran low in tumors compared with nearby healthy tissue, and low levels tracked more advanced disease. The authors propose linalool's pathway as a lead for stomach cancer drug design.
Catalog record
| CREATOR | Ying Hu, Shunfeng Chen, Yu Wang, Ling Liu, Chaoyi Zhang, Hong Chen, Yuanyuan Duanmu, Zhaotian Su, Jun Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |