Microbial, functional, and virulence biomarkers associated with familial risk of Crohn’s disease and ulcerative colitis
Gerard Serrano-Gómez, Soler Zaida, Marc Pons-Tarín, Luis Mayorga, Tarrat-Castells Maria, Borruel Natalia, Guarner Francisco, Chaysavanh Manichanh · 2026
Read Microbial, functional, and virulence biomarkers associated with familial risk of Crohn’s disease and ulcerative colitis by Gerard Serrano-Gómez, Soler Zaida, Marc Pons-Tarín, Luis Mayorga, Tarrat-Castells Maria, Borruel Natalia, Guarner Francisco, Chaysavanh Manichanh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13352609.txt.
Description
Gerard Serrano-Gómez leads a 2026 gut microbe study of families at higher risk of inflammatory bowel disease. Close relatives of patients carry raised risk and can reveal changes before illness starts. Shotgun sequencing covered stool from 68 Crohn disease and 77 ulcerative colitis patients, their healthy relatives, and 497 unrelated healthy controls.
Relatives kept normal microbe diversity but sat midway between patients and controls in imbalance. Crohn relatives shared patient-like losses, including depleted Faecalibacterium prausnitzii, and carried more adhesion and invasion genes. Yet their pathway profiles looked near-healthy, splitting taxonomic from functional change. Classifiers separated relatives from controls strongly using species and virulence gene patterns.
Catalog record
| CREATOR | Gerard Serrano-Gómez, Soler Zaida, Marc Pons-Tarín, Luis Mayorga, Tarrat-Castells Maria, Borruel Natalia, Guarner Francisco, Chaysavanh Manichanh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38069 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |