Topical resiniferatoxin for the treatment of vestibulodynia: a prospective observational trial
Filippo Murina, Cecilia Fochesato, Matteo Mantovani, Matilde Slanzi, Marianna Donini, Nicla Toni, Valeria Savasi · 2026
Read Topical resiniferatoxin for the treatment of vestibulodynia: a prospective observational trial by Filippo Murina, Cecilia Fochesato, Matteo Mantovani, Matilde Slanzi, Marianna Donini, Nicla Toni, Valeria Savasi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13352061.txt.
Description
Filippo Murina leads a 2026 pilot trial of a topical resiniferatoxin cream for vestibulodynia, the most common form of vulvodynia. The condition causes lasting pain at the vulvar vestibule when touched, and nerve overgrowth and receptor excess are thought to drive it. Standard care often gives partial relief or whole-body side effects.
Premenopausal women aged 18 years or older with at least 3 months of illness applied 10 mcg/mL cream once daily for 4 weeks with a measured dispenser. Pain scores, tolerability, and nerve measures were tracked. Resiniferatoxin strongly activates the TRPV1 receptor and can quiet pain fibres for a long stretch, so a local cream may target pain at its source.
Catalog record
| CREATOR | Filippo Murina, Cecilia Fochesato, Matteo Mantovani, Matilde Slanzi, Marianna Donini, Nicla Toni, Valeria Savasi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30668 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |