Dexime: A Selectively Enzyme‐Degradable Hydrogel for Protein Therapeutic Release
Quinton E. A. Sirianni, Nitzan Letko Khait, Adam Forman, Edward A. Armstrong, Karim Fouad, Molly S. Shoichet · 2026
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Description
Quinton E. A. Sirianni and co-authors set out in 2026 Dexime, a selectively enzyme-degradable gel for protein drug release. Gels guard protein drugs from denaturing shear and solvents. Dextrin, a starch-derived polysaccharide, has been largely skipped for gel design despite being biodegradable.
Dextrin tweaked with ketone or aldehyde groups was click-crosslinked with PEG tetraoxyamine to form dexime gels, whose stiffness and mechanics tune with dextrin share and pH. The gels jab through a 30-gauge needle, degrade selectively via alpha-amylase, yet stay stable and barely swell with other enzymes. Dexime gives an injectable, enzyme-triggered depot for sustained protein delivery that releases only where amylase is present.
Catalog record
| CREATOR | Quinton E. A. Sirianni, Nitzan Letko Khait, Adam Forman, Edward A. Armstrong, Karim Fouad, Molly S. Shoichet |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |