Pediatric sedation is not adult sedation in small: lessons from a PK/PD analysis of remimazolam
Hideyuki Asaka, Norifumi Kuratani, Hiroshi Nagasaka, Tina Nakamura, Tsutomu Mieda · 2026
Read Pediatric sedation is not adult sedation in small: lessons from a PK/PD analysis of remimazolam by Hideyuki Asaka, Norifumi Kuratani, Hiroshi Nagasaka, Tina Nakamura, Tsutomu Mieda (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13351712.txt.
Description
Hideyuki Asaka and co-authors argue in 2026 that sedation for children cannot simply copy adult practice, drawing on a drug-level analysis of remimazolam. Millions of children need sedation each year for scans and procedures. Common drugs each carry drawbacks, from breathing suppression with propofol to uneven effects with midazolam.
Remimazolam breaks down very fast in the body and can be reversed with flumazenil, and it is approved for adult procedural sedation with a simple dose plan. Child dosing, though, lacks models that reflect growth and development. The authors use pharmacokinetic and pharmacodynamic analysis to show why adult doses mislead and what child-specific data are still needed.
Catalog record
| CREATOR | Hideyuki Asaka, Norifumi Kuratani, Hiroshi Nagasaka, Tina Nakamura, Tsutomu Mieda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21491 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |