Salidroside alleviates TNF-α-induced endothelial inflammatory injury by modulating NF-κB/NLRP3 inflammasome-related signaling: an integrated network pharmacology and experimental study
Jiahui Meng, Weiwei Li, Lan He, Guoying Huang, Fang Liu · 2026
Read Salidroside alleviates TNF-α-induced endothelial inflammatory injury by modulating NF-κB/NLRP3 inflammasome-related signaling: an integrated network pharmacology and experimental study by Jiahui Meng, Weiwei Li, Lan He, Guoying Huang, Fang Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13351703.txt.
Description
Jiahui Meng and co-authors test whether salidroside can calm vessel lining injury linked to Kawasaki disease, in a 2026 combined computer and lab study. Kawasaki disease is a fever illness in children that can damage heart arteries. Salidroside comes from Rhodiola rosea and is known for anti-inflammatory effects.
Targets were predicted with screening tools and disease databases, then checked by docking models. Human coronary artery cells were stressed with TNF-alpha to mimic injury, and RNA sequencing tracked gene changes after treatment. Cell tests covered survival, movement, and cell death. Results point to NF-kappaB and NLRP3 pathways in the protective effect, though the work stays at lab stage.
Catalog record
| CREATOR | Jiahui Meng, Weiwei Li, Lan He, Guoying Huang, Fang Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42014 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |