Biologic effectiveness increases with earlier biologic initiation after severe asthma onset
Arjun Mohan, Reynold A Panettieri, Wendy C Moore, Njira L Lugogo, Wenjiong Zhou, Andrew W Lindsley, Donna D Carstens, Christopher S Ambrose · 2026
Read Biologic effectiveness increases with earlier biologic initiation after severe asthma onset by Arjun Mohan, Reynold A Panettieri, Wendy C Moore, Njira L Lugogo, Wenjiong Zhou, Andrew W Lindsley, Donna D Carstens, Christopher S Ambrose (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13351466.txt.
Description
Arjun Mohan and co-authors analysed in 2026 whether starting biologic drugs sooner after severe asthma begins improves their effect. Long uncontrolled inflammation scars and remodels airways, causing damage that later treatment cannot undo.
The analysis drew on a United States observational study of adults under specialist care for severe asthma. Among 244 patients starting a biologic with full data, flare rates in the year before treatment were compared with the year after, and factors tied to remaining flares were modelled. Earlier initiation was linked with greater benefit, supporting quicker escalation when standard inhalers fail rather than years of waiting.
Catalog record
| CREATOR | Arjun Mohan, Reynold A Panettieri, Wendy C Moore, Njira L Lugogo, Wenjiong Zhou, Andrew W Lindsley, Donna D Carstens, Christopher S Ambrose |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33399 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |