Exploring the organismal role of UFMylation in development, stress resilience, and neurological function in Caenorhabditis elegans
Charlotte Sophia Kaiser, Janina Kahl, Emily Jeanne Kouekem, Emma Schröder, Luka Ressmann, Antonio Miranda-Vizuete, Eva Liebau · 2026
Read Exploring the organismal role of UFMylation in development, stress resilience, and neurological function in Caenorhabditis elegans by Charlotte Sophia Kaiser, Janina Kahl, Emily Jeanne Kouekem, Emma Schröder, Luka Ressmann, Antonio Miranda-Vizuete, Eva Liebau (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13351140.txt.
Description
Charlotte Kaiser and six co-authors probe in 2026 what a protein-tagging system called UFMylation does for a whole animal, using the worm Caenorhabditis elegans. The system tags proteins to guard ribosome balance, stress response, and DNA repair. Mammals die without it, but worms survive, which opens a study window.
A gene edit knocks out the tag's core gene in worms. Mutants show shorter life, slow growth, and fertility faults, with more gonad trouble and sterility. Oddly, they also bear many stressors better, likely from a constant low stress response. Only the ER stress path switches on, not the mitochondrial one. Loss also worsens protein clumping in disease models, a caution for nerve health.
Catalog record
| CREATOR | Charlotte Sophia Kaiser, Janina Kahl, Emily Jeanne Kouekem, Emma Schröder, Luka Ressmann, Antonio Miranda-Vizuete, Eva Liebau |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |