TNAP-mediated hydrolysis of phosphorylated enamel matrix proteins drives local phosphate generation and enamel mineralization
Haya Kodama, Risako Chiba-Ohkuma, Ryuji Yamamoto, Shoji Hamanaka, Takatoshi Nagano, Yasuo Yamakoshi · 2026
Read TNAP-mediated hydrolysis of phosphorylated enamel matrix proteins drives local phosphate generation and enamel mineralization by Haya Kodama, Risako Chiba-Ohkuma, Ryuji Yamamoto, Shoji Hamanaka, Takatoshi Nagano, Yasuo Yamakoshi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13351139.txt.
Description
Haya Kodama and co-authors showed in 2026 how an enzyme generates phosphate inside developing tooth enamel, the most mineralised tissue in the body. Enamel needs a precisely timed phosphate supply, and where that phosphate is made locally was unknown.
In pig enamel, the enzyme TNAP was present and active across the secretory and growth stages. Extracts contained phosphate compounds, and blocking TNAP with a specific inhibitor cut phosphate production sharply. Purified enamel proteins fed to the human enzyme released phosphate directly. The work positions TNAP as the local phosphate factory that lets enamel crystals form on schedule.
Catalog record
| CREATOR | Haya Kodama, Risako Chiba-Ohkuma, Ryuji Yamamoto, Shoji Hamanaka, Takatoshi Nagano, Yasuo Yamakoshi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72893 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |