Development of LRRC15-binding disulfide-constrained peptides for PET imaging of cancer-associated fibroblasts
Benjamin J. Tombling, Fei Cai, Timothy J. Wendorff, Annie Ogasawara, Herman S. Gill, Jeff N. Tinianow, Andrew Chang, Aaron T. Balana, Lingling Peng, Stephen E. Miller, Benjamin T. Walters, Aaron Lictao, Qinying Yu, David C. DeWitt, Yuehua Wei, Sunny Z. Wu, Jawahar Sudhamsu, Akshay T. Krishnamurty, S · 2026
Read Development of LRRC15-binding disulfide-constrained peptides for PET imaging of cancer-associated fibroblasts by Benjamin J. Tombling, Fei Cai, Timothy J. Wendorff, Annie Ogasawara, Herman S. Gill, Jeff N. Tinianow, Andrew Chang, Aaron T. Balana, Lingling Peng, Stephen E. Miller, Benjamin T. Walters, Aaron Lictao, Qinying Yu, David C. DeWitt, Yuehua Wei, Sunny Z. Wu, Jawahar Sudhamsu, Akshay T. Krishnamurty, S (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13350978.txt.
Description
Benjamin J. Tombling and co-authors built in 2026 small peptides that bind LRRC15, a protein found only on cancer support cells, for PET imaging of the tumour microenvironment. Support cells that aid tumours are hard to image directly. Yet their presence shapes treatment response and outlook.
Using a joined library aided by machine learning, the team made locked peptides, notably ML-YSD-07 and ML-PD-03. These bound murine LRRC15 with subnanomolar strength and homed to LRRC15-expressing support cells. PET imaging with fluorine-18-labelled ML-YSD-07 showed specific tumour build-up in a mouse pancreas cancer model rich in LRRC15 support cells. The peptides give a targeted imaging tool for tumours driven by their stromal backing.
Catalog record
| CREATOR | Benjamin J. Tombling, Fei Cai, Timothy J. Wendorff, Annie Ogasawara, Herman S. Gill, Jeff N. Tinianow, Andrew Chang, Aaron T. Balana, Lingling Peng, Stephen E. Miller, Benjamin T. Walters, Aaron Lictao, Qinying Yu, David C. DeWitt, Yuehua Wei, Sunny Z. Wu, Jawahar Sudhamsu, Akshay T. Krishnamurty, S |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 98 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |