In vitro nano‑emodin–associated exosome‑mediated aPDT against Acinetobacter baumannii
Samane Teymouri, Hadiseh Mohammadpour, Maryam Pourhajibagher, Abbas Bahador · 2026
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Description
Samane Teymouri, Hadiseh Mohammadpour, Maryam Pourhajibagher, and Abbas Bahador combine plant compound carriers with light therapy against a drug-resistant wound bacterium. Their 2026 lab study targets Acinetobacter baumannii, whose biofilms shield it in burn wounds. The treatment packs nano-sized emodin into exosomes, tiny cell-made vesicles, and activates it with light.
The loaded vesicles killed standard and clinical strains, including multidrug-resistant ones, at low doses. They broke biofilms better than the compound alone, above all in the resistant isolates. Release ran fastest in acidic conditions like infected tissue, with minimal harm to red blood cells. Adding the light step silenced two biofilm genes many-fold. The authors back the pairing as a lab-stage strategy, while noting the vesicles act mainly as carriers.
Catalog record
| CREATOR | Samane Teymouri, Hadiseh Mohammadpour, Maryam Pourhajibagher, Abbas Bahador |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |